Host Immune Response to Chlamydia Infection
نویسنده
چکیده
1. protection against intracellular bacteria is mediated by T cells, which are interacting, not directly with the pathogen, but with the infected cell surface; antibodies exhibit a minor effect on the immune protection against intracellular infections; 2. infections by intracellular bacteria is accompanied by delayed hypersensitivity reactions that occur after the local administration of soluble antigens, mediated by T cells, whose effectors are macrophages; 3. tissular reactions to antiintracellular bacteria are granulomatous in nature, both the protective responses and pathology being caused by them. Breaking granuloma favors pathogen dissemination and extension of lesions; 4. intracellular bacteria are expressing little or no toxic effects to the host cell, and pathology results from the activation of the immune response, mediated primarily by T lymphocytes. In contrast, extracellular bacteria secrete extracellular toxins, some of them being extremely potent and producing direct tissue damage; 5. intracellular bacteria are well adapted for coexisting with the host cell for long periods, by maintaining a balance between the persistent infection and the protective immunity mechanisms, resulting in a long incubation period and the development of a chronic infectious process. The infection per se is distinct from the pathological process. In contrast, extracellular bacteria cause acute infections, which are triggered soon after infection and ending after the immune response reaches an optimal intensity.
منابع مشابه
Genotyping of Endocervical Chlamydia trachomatis Strains and Detection of Serological Markers of Acute and Chronic Inflammation in Their Host
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تاریخ انتشار 2012